Technical Papers
The following is a sample list of technical papers grouped by category. Click the Title to view the PDF.-
Animal Studies
Category Title Pump Used Specific Application Animal Studies Pathology Affects Different Organs in Two Mouse Strains Chronically Infectedby a Trypanosoma cruzi Clone: a Model for Genetic Studies of Chagas' Disease KDS-200 Deliver sterile saline solution to test mice, to avoid blood contamination of heart and liver samples Animal Studies Relaxin is a Potent Renal Vasodilator in Conscious Rats KDS-200 Administer N-~nitro-L-Arginine methyl ester (L-NAME) intravenously to female rat test subjects Animal Studies Preferential Increases in Nucleus Accumbens Dopamine after Systematic Cocaine Administration are Caused by Unique Characteristics of Dopamine Neurotransmission KDS-100 Administer 100 nmol of RTI-76, dissolved in 10ul of saline solution, to test electrical effects of cocaine/dopamine on rat brains Animal Studies A Reproducable Model of Circulatory Arrest and Remote Resuscitation in Rats for NMR Investigation KDS-210P Slow infusion of oxygenated arterial blood, to resuscitate study rats Animal Studies Concurrent Auto-Receptor-Mediated Control of Dopamine Release and Uptake during Neurotransmission: An In Vivo Voltammetric Study KDS-100 Administer 100nmol of RTI-76, dissolved in 10ul of saline solution, to test electrical effects dopamine neurotransmission Animal Studies Circadian Differences in Stress-Induced Pressor Reactivity in Mice KDS-220 Administer heparinized saline solution by catheter, to make cardiovascular measurements in test mice Animal Studies Allergic Lung Responses are Increased in Prostaglandin H Synthase-deficient Mice KDS-200 Intravenous infusion of doses of Mch in PBS, for precise timing of a cholinergic agonist Animal Studies Glucose Stimulates Protein Modification by O-linked GlcNAc in Pancreatic ß cells; Linkage of O-linked GlcNAc to ß Cell Death KDS, possible KDS-100 Infuse glucose or glucosamine in lab rats Animal Studies Dependence of Early Cerebral Reperfusion and Long-Term Outcome on Resuscitation Efficiency After Cardiac Arrest in Rats KDS, possible KDS-100 Long-term resuscitation of cardiac arrested rats, by infusion of solution into femoral artery Animal Studies Facilitory Role of NO in Neural Norepinephrine Release in the Rat Kidney KDS-100 Drug infusion in an isolated pump-perfused rat kidney Animal Studies Functional Properties of Spontaneous EPSCs and non-NMDA Receprots in Rod Amacrine (AII) Cells in the rat Retina KDS-220P Ultra-fast application of glutamate to test rat retina receptor cells Animal Studies Islet Hyperperfusion during prediabetic phase in OLETF rats, a model of type 2 diabetes - Otsuka-Long-Evans-Tokushima fatty rats KDS-120 Withdraw reference blood sample from rat, used in diabetes testing Animal Studies The Survival and Migration Pattern of the Bone Marrow Stromal Cells after Intracerebral Transplantation in Rats KDS ("Micro-infusion Pump") Possible KDS-310 Transplant rat brain cells to subject rats on Kopf stereotaxic frame Animal Studies Circadian blood pressure and heart rate rhythms in mice KDS-220 Infuse heparinized saline solution, to maintain blood pressure in test mice (Biology/physiology) Animal Studies Selective inhibition of 11ß-Hydroxysteriod Dehydrogenase Type 1 Improves Hepatic Insulin Sensitivity in Hyperglycemic Mice Strains KDS-100 Administer blood glucose to test mice to maintain blood glucose levels during insulin infusion (Biology / Medicine / Endocrinology) Animal Studies Role of the ß3-Adrenoceptor in Urine Storage in the Rat: Comparison between the Selective ß3-Adrenoceptor Agonist, CL316, 243, and Various Smooth Muscle Relaxants KDS-100 (Muromachi) Provide continuous infusion of saline into a rat bladder, during drug testing of smooth muscle relaxant (Pharmacology / medicine) Animal Studies Colon Water transport in transgenic mice lacking aquaporin-4 water channels KDS-100 Infuse saline solution into rats in vivo, to test colon permeability (Biology/physiology) Animal Studies Survival in a rat model of lethal hemorrhagic shock is prolonged following resuscitation with a small volume of a solution containing a drag-reducing polymer derived from aloe vera KDS-100 Infuse resuscitation fluids into volume-controlled hemorrhaging rats, to test efficiency of new aloe-based drag-reducing polymer Animal Studies Hippocampal Damage and Exploratory Preferences in Rats: Memory for Objects, Places and Contexts KDS Infuse chemical (NMDA) into rat brain hyppocampi (simulate brain damage) prior to testing memory functions Animal Studies Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA KDS Intraconjunctival injection of test solutions in rats (biology, nucleic acid research) Animal Studies Rapid Elevation of Plasma Interleukin-6 by Morphine Is Dependent on Autonomic Stimulation of Adrenal Gland KDS-101 Microinjecting morphine into rat brains for experimental theraputics of the autonomic system Animal Studies Coordinated regulation of gastric chloride secretion with both acid and alkali secretion KDS-260 Used to perfuse rat stomach lumen for gastric secretion measurements (Gastrointestinal and Liver Physiology) Animal Studies Evaluation of systemic blood NO dynamics by EPR Spectroscopy: HbNO as an endogenous index of NO KDS-100 Intravenous drug infusion into rats (Heart and Circulatory Physiology) Animal Studies Residual Oil Fly Ash Amplifies Allergic Cytokines, Airway Responsiveness, and Inflammation in Mice KDS-200 Fluid delivery of Methacholine (MCh) to test rats airway responsiveness to chemical (respiratory medicine, Asthma) -
Bioreactors
Category Title Pump Used Specific Application Bioreactors Load Dampening system for vapor phase Bioreactors KDS-200 Inject pure phase compounds (aerosol) into bioreactor to test dynamic load response to chemicals (waste management) -
Cell Biology
Category Title Pump Used Specific Application Cell Biology Holding Forces of Single Particle Dielectrophoretic Traps KDS-101 Provide destabilizing fluid flow for testing stability of electrically produced single-particle traps (Cell Biology applications) Cell Biology Role of Surface Proteins in the Deposition Kinetics of Cryptosporidium Parvum Oocysts KDS-230 Used to transfer oocyst suspension medium for deposition (adhesion) experiments (water treatment for parasites) Cell Biology Comparison of Cell Biology and Biomass Specific Activities of Dominant Bacterioplankton Groups on Stratified Waters of the Celtic Sea KDS, Possible KDS-310 ("Microinjector") Provide control group for counting bacterial beads in standard stock suspension (marine biology) Cell Biology Avidity Modulation Activates Adhesion under Flow and Requires Cooperativity among Adhesion Receptors KDS Provide flow for flow chamber experimentation on cells (Genomics, Pathobiology) Cell Biology Phosphatidylinositol 3-kinase g mediates shear stress-dependent activation of JNK in Endothelial cells KDS Provide flow through parallel place shear chamber, providing non-pulsating, laminar shear forces on test cells (Molecular cell biology) Cell Biology Capacitance Cytometry: measuring biological cells one by one KDS-210 Used to deliver fluid to a microfluidic device at nonpulsatile rates ranging from 1 µl/hr to 300 µl/hr (Cell Biology/Physics) Cell Biology Intravascular Metastatic Cancer Cell Homotypic Aggregation at the Sites of Primary Attachment to the Endothelium KDS-210 Component of an in vitro parallel plate laminar flow chamber, to study the adhesion of MDA-MB-435 and DU-145 cells to HBMECs (Cancer Research/Medicine) Cell Biology Inhibition of Phosphatidylinositol 3-Kinase Enhances Mitogenic Actions of Insulin in Endothelial Cells KDS (programmable) Infuse Endothelial cells derived from mouse lung endothelium into salt solution with controlled physiological shear rates, to test for selective insulin resistance (Biological Chemistry) Cell Biology Nitric Oxide promotes IntraCell Biology calcium release from mitochondria in striatal neurons KDS NO-containing saline was superfused to study the effect of NOS activity on the NMDA-evoked [Ca2+]i increases of Striatal neurons (Neurobiology) Cell Biology Cited1 is required in Trophoblasts for Placental Development and for Embryo growth and survival KDS-200 Used to perfuse a mouse carotid artery with saline solution, prior to addition of a resin mixture, to make an internal vascular cast of the mouse heart (molecular and Cell Biology biology) Cell Biology Fast Kinetics of Chromatin assembly revealed by single-molecule videomicroscopy and scanning force microscopy KDS DNA Molecules were floated in solution, and flowed past a videomicroscope for study of chromatin assembly procedures (biophysics) -
Chemical
Category Title Pump Used Specific Application Chemical The aqueous geochemistry of the rare earth elements and Yttrium. Part X. Potentiometric determination of stability constants of acetate complexes of La3+, ND3+, Gd3+ and Yb3+ at 25-70 °C and 1 Bar KDS-210 Pump supply for both calibration and stability constant measurements of aqueous geochemistry solutions. -
Chemical Engineering
Category Title Pump Used Specific Application Chemical Engineering Estimating the Efficiency of Cell Capture and Arrest in Flow Chambers: Study of Neutrophil Binding via E-selectin and ICAM-1 KDS Used to simulate a uniform laminar flow field in a flow chamber.(Bioengineering, Chemical Engineering) Chemical Engineering Particle Deposition onto Solid Surfaces with Micropatterned Charge Heterogeneity: The "Hydrodynamic Bump" Effect KDS-230 Used to pump a colloidal suspension into a glass cell, for deposition experiments (Chemical / Environmental Engineering) Chemical Engineering Beyond Webcams: An Introduction to Online Robots: (Other Applications): Telerobotic Remote handling of Protein crystals via an internet link KDS-210P Computer controlled pump action, used in an adjustable mount, for precision displacement of capillary fluids, remotely Chemical Engineering The Treatment of Waste-air Containing Mixed Solvent using a Biofilter: 1. Transient Behavior of Biofilter to Treat Waste-air Containing Ethanol KDS-200 Used to inject Ethanol into humidified air, to simulate waste-air gasses, testing a biofilter apparatus (Chemical Engineering) Chemical Engineering Adhesion Kinetics of Viable Cryptosporidium parvum Oocysts to Quartz Surfaces KDS-230 Pump Oocyst suspension onto capillary tube with quartz cover, to measure adhesion (Chemical Engineering) -
Chemical Gardens
Category Title Pump Used Specific Application Chemical Gardens Oscillatory growth of Silica Tubes in Chemical Gardens KDS-200 Hydrodynamic injection of Aqueous metal salt solution into Sodium Silicate solution, to create silica tubes (Chemistry and Biochemistry) -
Chemistry
Category Title Pump Used Specific Application Chemistry Analytical Characterization of Electrochemical Biosensor Test Strips for Measurement of Glucose in Low-Volume Interstitial Fluid Samples KDS-200 Glucose measurement studies: surrogate sample delivered to test strip through ISF collection needle. (Clinical Chemistry) -
Drug Delivery
Category Title Pump Used Specific Application Drug Delivery Powder Properties and their influence on dry powder inhaler delivery of an antitubercular drug KDS-100 Used to dispense mixed chemicals (continuous phase and disbursed phase) prior to drying as a powder mixture (Pharmacy) Drug Delivery Use of Relaxin to treat diseases related to vasoconstriction KDS Drug infusion (pharmaceutically active relaxin) for treatment of hypertension (?) -
Electrospinnning
Category Title Pump Used Specific Application Electrospinnning Tailoring Tissue Engineering Scaffolds Using Electrostatic Processing Techniques: A Study of Poly(Glycolic Acid) Electrospinning KDS, possible KDS-100 Providing metered dispensing of Polyglycolic acid for electrostatic spinning, producing smaller diameter fibers for tissue engineering scaffolds Electrospinnning Simultaneous electrospinning of two polymer solutions in a side-by-side approach to produce bi-component fibers KDS-100 Control flow rate of two polymer solutions, in a bicomponent electrospinning device -
Environmental
Category Title Pump Used Specific Application Environmental Evaporation Rates and Vapor Pressures of Individual Aerosol Species Formed in the Atmospheric Oxidation of a- and ß-Pinene KDS-200 Tandem Differential Mobility Analyzer (TDMA) experiment. Syringe pump feeds an atomizer for continuous aerosol output. -
Gas Chromotograph
Category Title Pump Used Specific Application Gas Chromotograph Development of New Type LC-Capillary Column using Wide Bore Open-Tubular Capillary Column for GC KDS-100 Inject sample quantity into capillary column, for Chromatography instrumentation testing -
Genetic Engineering
Category Title Pump Used Specific Application Genetic Engineering Silencing of Midgut Aminopeptidase N of Spodoptera litura by double-stranded RNA Establishes Its Role as Bacillus thuringiensis Toxin Receptor KDS-200 Injection of special RNA into insects, which leads to pore formation and death. (genetic engineering, possible insecticide technology?) -
Mass Spec
Category Title Pump Used Specific Application Mass Spec Interfacing Sequential injection on-line preconcentration using a renewable micro-column incorporated in a 'lab-on-valve'system with direct injection nebulization inductively coupled plasma mass spectrometry KDS-101 Carrier/sample delivery into an ICP (Mass spectrometry) -
Microbiology
Category Title Pump Used Specific Application Microbiology Bacterial Adhesion and Transport in Porous Media: Role of the Secondary Energy Minimum KDS-200 Bacterial transport experiments (microbiology, chromatography?) Microbiology Identification and glucan-binding properties of a new carbohydrate-binding module family KDS-200P Quantitative UV analysis of substrate binding of newly discovered carbohydrate-binding module family (microbiology) -
Microfluidics
Category Title Pump Used Specific Application Microfluidics Silica tubes in Chemical Gardens: Radius selection and its hydrodynamic origin KDS-200 Used to deliver cupric sulfate solution into waterglass (Na2SiO3), for producing crystaline chemical garden Microfluidics Sequence-selective DNA detection using multiple laminar streams: a novel microfluidic analysis method KDS-230 Control all injections of solutions into a microchannel for selective DNA sequence analysis Microfluidics Effects of Rectangular microchannel aspect ratio on laminar friction constant KDS Accurate testing of micromachined pipette arrays (microfluidics study, micromachined channels Microfluidics A barrier embedded Kenics micromixer KDS Micromixing, fluidics Microfluidics Tranport of particle-laden fluids through fixed-valve Micropumps KDS-200 provide known flow rate for flow resistance tests on micropumps Microfluidics Laminar drag reaction in microchannels using ultrahydrophobic surfaces KDS-100 Drive fluid through experimental microchannel flow cell, to create an ultra-hydrophobic surface (Mechanical/Industrial Engineering) Microfluidics An investigation of Knoevenagel condensation reaction in microreactors using a new Zeolite catalyst KDS Used to feed liquid reactants into microchannels cut into porous stainless steel. (Part of microreactor housing) (Chemical Engineering) Microfluidics Catalytic Slurry Hydrogenation of 0-nitroanisole in a Flow Microreactor with in-situ Generation of Hydrogen KDS Fluid flow through Micro mixer tubing, experimental process for Hydrogen production -
Mircrosystem
Category Title Pump Used Specific Application Mircrosystem Microfabricated Cyclical Electrical Field flow Fractionation KDS Provide flow through Microfabricated electrical field flow microsystem (Mechanical Engineering) -
Textile
Category Title Pump Used Specific Application Textile Textile ink jet performance and Print Quality Fundamentals KDS-230 Pump ink supply for ink jet applications testing (textile industry) -
Waste Management
Category Title Pump Used Specific Application Waste management Characterization of the changes in polarity of natural organic matter during solid phase extraction: introducing the NOM polarity rapid assessment method (NOM-PRAM) KDS-100 Maintain fluid flow through an experimental waste water test setup (Waste Water treatment) -
Water Treatment
Category Title Pump Used Specific Application Water Treatment Enhanced removal of natural organic matter via peroxydase-mediated oxidative coupling KDS Continuous injection of fulvic acid solutioninto semicontinuous flow reactors (water treatment testing)
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The NEW KD Scientific™ Peristaltic Pump System allows maintenance free, continuous flow pumping of various liquids. The fluids pumping contacts only the inside surface of the tubing negating concern for the valves, O-rings or seals that might be incompatible with fluid being pumped. • Intuitive Touch Screen • User Configurable Multi-Step Operation • Flow Rate & Key Parameters are Clearly Displayed • Selectable Tubing Table • Automatic Tubing Break-In • Easy-to-maintain KD Scientific Inc. 84 October Hill Road Holliston, MA 01746 USA Phone: 1-508-429-6809 Fax: 1-508-893-0160 Email: info@kdscientific.com
